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It has been proposed that the circulating peptide could access the brain via the ARC and exert its anorectic actions through indirect activation of pro-opiomelanocortin (POMC) neurons in the hypothalamus and through the blocking of fasting ghrelin levels

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HSL shows a preference for activity against fatty acids in the sn-1 or sn-3 position (99)

This study offers valuable insights into the mechanisms underlying persistent VCD associated with long COVID and highlights the therapeutic potential of vitamin B12 as an epidrug to prevent or mitigate this impairment