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6A, Fig S6)
when this process is compromised, Fe + activates lipid peroxidases, producing reactive oxygen species (50), which oxidize membrane polyunsaturated fatty acids (PUFAs) to PUFA-OOHs, resulting in irreversible membrane damage and cellular apoptosis ( Figure 4 )
Most Japanese whitening items use safer alternatives like arbutin or tranexamic acid
Postmortem studies using healthy subjects have shown that neuromelanin formation is a normal process in substantia nigra
