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Low molecular weight HEPs can inhibit the production of NO, iNOS, and inflammatory cytokines (including TNF-, IL-1, and IL-6) stimulated by LPS and dextran sulfate sodium (DSS) as well as inhibit activation of the NLRP3 inflammasome and phosphorylation of NF-B, AKT, and MAPK, thereby enhancing immune function and indicating its potential therapeutic efficacy for acute ulcerative colitis [55]

It is more prevalent in middle-aged adults

Although suicidal and vital NETosis share notable common mechanisms among their key steps, including NET assembly and release, they lead to vastly different outcomes for neutrophils

The DNA lesions, in turn, trigger a series of signal-transduction pathways, leading to cell-cycle arrest, DNA repair and apoptosis