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Two ENM suspensions at identical mass concentrations but with different primary particle sizes will present vastly different total surface areas and particle numbers to a biological system, resulting in dramatically different toxic potentials

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Sutovsky P, Schatten G (1997) Depletion of glutathione during bovine oocyte maturation reversibly blocks the decondensation of the male pronucleus and pronuclear apposition during fertilization1

Badawy AA (2021) Multiple roles of haem in cystathionine -synthase activity: implications for hemin and other therapies of acute hepatic porphyria