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A key mechanism underlying MOTS-c action is the activation of AMP-activated protein kinase (AMPK), a central regulator of cellular energy balance
Patients should also be aware that folate supplementation should not be started before B12 deficiency has been treated, as doing so can precipitate or worsen neurological complications
However, PRP is not always suitable for patients who have a history of clotting, bleeding, or other blood disorders or a history of some cancers, including skin cancer
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