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Nrf2 signaling deficits in diabetic mice have been linked to BBB disruption [219]
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Consistently, the livers of HFD-fed mice showed increased IKK--SSG levels, decreased IKK- phosphorylation, and suppressed NF-B activation when compared to these from control animals
The incidence of gallstones is increasing and is expected to rise dramatically with the increase in the longevity and the risk factors such as obesity
