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The function of HNMT is entirely dependent on the body's methylation cycle, which strictly requires Vitamin B12 to operate
Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions
Am J Hematol 95(10):1127-1134, 2020
this combination of diseases is known as Harding's syndrome or LHONMS [258, 259]
