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Planta 236:765779 Pignocchi C, Kiddle G, Hernndez I, Foster SJ, Asensi A, Taybi T, Barnes J, Foyer CH (2006) Ascorbate oxidase-dependent changes in the redox state of the apoplast modulate gene transcript accumulation leading to modified hormone signaling and orchestration of defense processes in tobacco

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The reactive oxygen species (or the oxidative damage it causes) should always be demonstrable at the site of injury