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Epithalon addresses the genomic instability dimension (telomere attrition)
doi: 10.3389/fimmu.2021.629807
In addition, there is a higher intensity of CD38 expression (measured by flow cytometry) in the more aggressive multi-hit variants, which allows further differentiation of the diseases and the use of CD38 as a biomarker for early diagnosis [14]
The study interestingly showed that sera from COVID-19 patients triggered NET release from control neutrophils in vitro, indicating that circulating NETs can potentially be used to predict the extent of disease severity
