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Data were quantified using ImageJ software and normalized to the control group

People with Kidney Disease The kidneys play a central role in processing and excreting glutathione metabolites

In addition, ferroptosis inducers such as erastin and Sorafenib significantly upregulated the protein expression level of S1R but not the mRNA level, suggesting a transcription-independent role of S1R in ferroptosis [152]

Cytochrome P450 4F2 (CYP4F2) initiates -oxidation of tocochromanols, a process that is followed by -oxidation to carboxyethyl hydroxychromanol (CEHC), which can be conjugated with glucuronide or sulfate and excreted in urine or bile