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In transgenic mouse experiments, TFAM overexpression not only increased the mtDNA copy number in mouse hearts by approximately 2-fold but also, under volume overload (VO) conditions, inhibited the production of mitochondrial reactive oxygen species (mitoROS), reduced the activity and abnormal upregulation of MMP-2/9, ultimately alleviating eccentric myocardial hypertrophy, improving cardiac function, and causing no damage to mitochondrial enzyme activity (155)
Diabetologia 63:19992006 Mallone R, Halliez C, Rui J, Herold KC (2022) The -cell in type 1 diabetes pathogenesis: a victim of circumstances or an instigator of tragic events
Anti-Aging Properties Glutathiones antioxidant capabilities help neutralize free radicals, which contribute to skin aging
