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Additionally, VQ lacking the target small molecule (VQ-N) generated only low-level background signals and did not recapitulate the pronounced variant-specific peaks observed with Berberine-VQ-N 3 (NMe 2 ), supporting that the variant-specific RT-deletions primarily arise from target ligand-dependent binding (Supplementary Fig

This disruption prevents metabolic reprogramming toward an effector phenotype, inhibiting Teff cell differentiation while potentially favoring Treg generation

After treatment with KA, the number of IBA1-positive microglia was significantly increased in the hippocampus of KA-treated mice compared to mice in the control group (Fig

Choueiri TK, Bauer TM, McDermott DF, Arrowsmith E, Roy A, Perini RF, et al