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The marked difference in safety between clinic and home treatments underscores the need for qualified professional care for any anal bleaching procedure

The D (4,3) values remained relatively constant throughout the study, ranging from 198 1 nm on day 1 to 193 1 nm on day 30, without statistically significant differences between time points (Supplementary Figure S1)

Protective action on the renal system Acute kidney injury (AKI) manifests itself as an independent cause of mortality (Rewa and Bagshaw, 2014), and may also be seen as a co-morbidity in several diseases (Pereira et al., 2012)

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