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Additionally, NAD + is required for fatty acid metabolism during -oxidation, glutaminolysis generating -ketoglutarate, mitochondrial shuttling of metabolites, and lactic acid fermentation 35

Oral administration significantly reduces lipogenic activity and increases lipolytic activity in adipose tissue, with concurrent increases in fat and glucose oxidation and elevated energy expenditure

Phase 4: AOD 9604 cycle break (week 17+) After 12-16 weeks of AOD 9604, discontinue it for a 4-week break while continuing tirzepatide

Moreover, this study reported that NR supplementation did not impact NAD + levels in the muscle of Nampt knockout mice