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Description
In contrast to most other ABC transporters 50 , ABCC1 is able to efflux drugs in the presence of GSH and/or in the form of GSH-conjugates 51
The balance between GSH and GSSG is a critical determinant in the proper functioning of various cellular pathways [8,13,14]
Chem Rev 108: 16141641, 2008
Such trials should ideally investigate the impact of methotrexate alone, folic acid alone and methotrexate in combination with folic acid and include a non-methotrexate/folic acid comparator arm to fully determine the atheroprotective potential of methotrexate
