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Evidence: Green tea consumption is associated with lower serum folate in pregnant women Animal studies show neurodevelopmental effects from high-dose green tea Some studies report increased neural tube defect risk with daily tea consumption Who should avoid: Pregnant women (especially during the periconceptional period) Children with neurological or developmental issues Anyone with diagnosed cerebral folate deficiency Why Standard Treatment Falls Short The standard approach focuses almost entirely on prescription Leucovorin (folinic acid)typically 5-50 mg daily

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Ecotoxicol Environ Saf 72:199205 Barron MG, Hansen JA, Lipton J (2002) Association between contaminant tissue residue and effects in aquatic organisms

Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species