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Description
Most users begin noticing appetite changes in the first few weeks and measurable weight loss by weeks 48

Bacterial contamination may not show obvious signs

[DOI] [PubMed] [Google Scholar] [37].Hu YJ, Diamond AM, Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium
It depends on your individual needs, but most people start with weekly injections before switching to monthly maintenance
