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Dual BCL-XL/2 Protac 753B Not Only Potently Induces Apoptosis in Venetoclax-Resistant Primary AML Cells but Also Effectively Eliminates Chemotherapy-Induced Senescent AML Cells

However, it has also been observed that SIRT6 can suppress CAT activity by binding to the CAT promoter, leading to an overexpression of ROS