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Gastroenterology 126:287 Whittle BJR, Boughton-Smith NK, Moncada S (1992) Biosynthesis and role of the endothelium-derived vasodilator, nitric oxide in gastric mucosa
The two are structurally unrelated and act through different biological pathways, which is the main reason researchers became interested in studying them in combination

O'Connor MK, Nicholson R, Epstein C, et al

Research suggests they are peptides that reduce inflammation, promote cellular regeneration, and improve circulation
