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Conversely, when oxidative challenges exceed physiological levels, they can disrupt redox signaling and cause oxidative damage to biomolecules, termed oxidative distress

doi:10.1016/j.freeradbiomed.2005.04.020

The Nobel Assembly said in a news release Monday that the three scientists made seminal discoveries that led to the identification of a novel virus. It said the trio had made a decisive contribution to the fight against blood-borne hepatitis, a major global health problem that causes cirrhosis and liver cancer in people around the world. Globally, an estimated 71 million people have chronic hepatitis C virus infection, according to the World Health Organization