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The tirzepatide molecule is actually slightly more sensitive to temperature fluctuations than semaglutide, which is why Mounjaro has a shorter room-temperature window (21 days) compared to Ozempic (56 days)

However, side effects can occur, such as nausea, digestive issues, or injection site reactions

[11] It is important to distinguish between metformin causing neuropathy directly versus contributing to it through vitamin deficiency

This paper did say, specifically to the GLP-1 receptor agonist, just said there are pro-inflammatory cytokines, including TNF-alpha, IL-6, IL-1, are suppressed by the GLP-1R in immune cells
