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Statements Author contributions LS conceived and designed the study

Blood Cells Mol Dis 46(2):159165 Lipschitz DA, Mitchell CO, Thompson C (1981) The anemia of senescence

Although the specific mechanisms are not entirely clear, increasing evidence indicates that the CYP pathway has potential as a therapeutic target in these two disease areas

Interestingly, we observed a 2-3 fold elevated PSPH gene and protein expression in 2012.2 cells under hypoxic conditions ( p = 0.0098 and p = 0.0082), whereas 1919 cells did not exhibit upregulation of PSPH expression (Fig