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Description
Toxicology 2006

doi: 10.3390/nano12152621

While 5% lidocaine patches act by blocking sodium channels to reduce peripheral nerve firing, 8% capsaicin patches induce nociceptor defunctionalization through sustained activation and subsequent desensitization of the TRPV1 receptor [370]

The DNA methylation profile (methylome) is inherited (maintenance DNA methylation), while the formation of new sites is de novo DNA methylation
