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Description
In subsequent experiments with mouse xenografts, short-term CB-839 treatment reduced serum glutathione levels by at least 50%, while tumor xenografts showed a 30% increase in response to radiotherapy

Caspases: intracellular signaling by proteolysis

Our findings that mitAspAT catalyzes a cysteine S -conjugate -lyase reaction with TFEC in vitro and is syncatalytically inactivated in the process (Cooper et al., 2002a) are consistent with the in vivo finding that this enzyme in the kidney is thioacylated after administration of TFEC to rats (Cooper et al., 2011)

eLife 10 , e66747 (2021)
