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Spirulina also reduces endothelial cell migration and tube formation and decreases metalloproteinase activity, including MMP-2, MMP-9, and MCP-1, contributing to its anti-angiogenic profile [95,98]

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The mechanism of covalent attachment of nitric oxide to proteins is termed S-nitrosylation

Cisplatin upregulates the expression of tumor necrosis factor (TNF-) (Kaur et al., 2011