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Among these genes, REPRIMO and p16 , key regulators of the cell cycle, exhibited significantly higher methylation rates in esophageal cancer patients non-responsive to chemoradiation, and promoter methylation of both genes impairs the ability to arrest at the G2/M checkpoint, where cisplatin exerts their effects, leading to chemoresistance [116, 117]

However, accelerated energy metabolism that supports the enhanced proliferation rate further increases iron demand, oxidative stress, and susceptibility to tumor cell death [14]

Check the label if you have coeliac disease or a diagnosed gluten intolerance

Inflammopharmacology 29 (4), 11571168