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A review found that for people without advanced neurological disorders, vitamin B12 supplements are unlikely to improve brain function
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DNA synthesis and cell metabolism Intracellular conversion of vitamin B 12 to two active coenzymes, in mitochondria and adenosylcobalamin in the cytoplasm, is necessary for the homeostasis of methylmalonic acid and homocysteine, respectively

These findings have led to increased interest in evaluating the therapeutic potential of VEGF as a neuroprotective agent in neurodegenerative diseases (Storkebaum and Carmeliet 2004)
