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Cushing syndrome, an endocrine disorder characterized by chronic endogenous or exogenous GC overexposure, increases visceral and trunk subcutaneous adipose tissue and causes insulin resistance
doi: 10.1074/jbc.M110.186999 141 LemK
PUMA mediates cell apoptosis in response to the tumor necrosis factor (TNF)-related apoptosis-inducing ligand and ferroptosis inducers, and p53 may regulate ferroptosis and apoptosis as a key factor in the crosstalk of the two death mechanisms through PUMA regulation (74)
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