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Description
Within adipocytes and skeletal muscle the PKC isoform, PKC/, phosphorylates proteins associated with intracellular vesicles containing the glucose transporter, GLUT4, resulting in their migration to, and fusion with, the plasma membrane
They act as rate-limiting enzymes in their respective pathways (Grenett et al., 1987)
Large human metaanalyses do not show headaches as a common or serious adverse event, but headaches are reported by a minority and in some trials and postmarketing data
doi: 10.1371/journal.pone.0100627 46
