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Q Shi performed luciferase reporter assays, indicating that miR-25 directly regulates MITF expression by binding to the predicted target sites in the 3UTR of its mRNAs (120)

The incorporation of unsaturated tail groups into ionizable lipids, the introduction of environmentally responsive PEGylation, the addition of polymers and antibodies to enhance membrane rupture, and the improvement of LNP's ability to escape endosomes through active modulation of endosomal recycling pathways provide a theoretical foundation for subsequent studies

It has been reported that protein PARK7/DJ-1 [159], lncRNA MALAT1 [160], and (possibly) HDACs [161] participate in the regulation of HIF-1 and pVHL binding