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In short, 5-Amino-1MQ acts as a metabolic/epigenetic node by inhibiting NNMT, thereby impacting NAD flux and methylation potential rather than directly activating a receptor

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It also supports immune system function, making it valuable for cows in varying stages of life, from calving to lactation

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss