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Interest in DSIP research declined over time, partly because of mixed clinical findings and partly because peptide research funding shifted toward other compounds
Following single and repeat doses from 6 to 20 mcg/kg over 6 weeks, gross necropsy revealed no adverse organ changes
reported a decreased mucus thickness in the colon of cirrhotic patients and a breakdown of E-cadherin and occludin by endogenous and newly identified bacterial proteases respectively, which could be future therapeutic targets (151)
