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The 5-hydroxymethyl-2-furoic acid values were higher in patients exposed to mold vs the control patients (9.11 vs 2.91 mmol/mol of creatinine) (p value= 0.00075)

Apart from this, research over the years has also reported the complex interplay of probiotics and their metabolites in the modulation of PI3K/Akt/mechanistic target of rapamycin kinase (mTOR) signalling pathways, which is one of the dysregulated pathways in various cancers, including brain cancers [49, 270, 271]

However, the efficiency of gene silencing by naked siRNA is very low, because the naked siRNA molecules are rapidly degraded by nucleases in the bloodstream and experienced rapid renal clearance in the body 19,20

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