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Furthermore, sodium-containing formulations should be judiciously avoided in topical preparations, while fully optimized delivery systems are indispensable for enhancing transdermal NSAID penetration, enabling precise targeting to inflammatory foci, and achieving synergistic therapeutic outcomes through dual anti-inflammatory and crystal-dissolving mechanisms (Hooper and He, 2022)

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A clinical case series reported that DSIP administration during opioid detoxification reduced withdrawal severity and improved sleep quality in patients undergoing tapering protocols (Iyer et al., Neurosci Biobehav Rev, 1988

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Additionally, as the closely interrelated increased pressure in the three body cavities was rapidly transmitted through the venous system [23] (and thereby, the venous system can be seen as a therapy target [14,15,16,17,18,19,20,21,22,23]), the brain swelling and lesions and increased pressure in the superior sagittal sinus may induce a comparable deadly syndrome [20]

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