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Metabolomics analyses revealed a time-dependent increase in tricarboxylic acid cycle intermediates during ES treatment, suggesting that copper toxicity primarily disrupts the tricarboxylic acid cycle rather than oxidative phosphorylation (180,181)

nature.comMC Jimnez-Lpez, AC Moreno-Maldonado, N Martn-Morales, F OValle, MR IbarraScientific Reports, 2025nature.com 15 (2025)

In Long COVID, this endothelial damage promotes immunothrombosis, the formation of microscopic blood clots (microclots) that block tiny capillaries and prevent oxygen from reaching vital tissues like the brain and muscles

These studies imply that the transition from lab methods to field management strategies is worth pursuing