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We are grateful to Gene Denovo (Guangzhou, China) for assisting in the bioinformatics analysis in this study

In PD, apoptosis plays a significant role in the pathological mechanisms underlying the loss of dopaminergic neurons in the SNpc caused by oxidative stress and mitochondrial dysfunction

The US FDA has studied the data of 254 medicines in the LTKB-BD (Liver Toxicity Knowledge base Benchmark Dataset) and found that regardless of the administered dose, drugs metabolized by cytochrome P450 (CYP) enzymes CYP1A2, CYP2C8/CYP2C9 and CYP3A5 were more likely to cause DILI (Yu et al., 2014)