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The employment of concurrent therapeutic and imaging mechanisms, incorporation of unconventional biomaterials possessing enhanced spatiotemporal management within scaffolds, manipulation of the discharge of diverse bioactive agentsnotably growth factorsto govern the trajectory of stem cells and morphogenesis, regulation of the mechanical potency of scaffolds for hard tissue utilization, and reduction of toxicity and improvement of biocompatibility via tissue-targeted administration constitute a range of potential uses for NPs in TERM (198, 199)

Nonetheless, the predictive value of existing maker for immunotherapy like PD-L1 status in ESCC is unsatisfactory [136]

- Vitamin C (Ascorbic Acid): Collagen booster - essential for collagen synthesis, brightens skin, strengthens immune system, protects against oxidative stress

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