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Its anti-inflammatory supportive properties are particularly noteworthy in the context of chronic inflammatory conditions, such as inflammatory bowel disease (IBD), arthritis, and various skin disorders

In people who have ulcerative proctitis that has not spread, surgery is rarely required, cancer rates are not increased, and life expectancy is normal

When deficiency is suspected based on clinical features (fatigue, paraesthesia, cognitive changes) or risk factors (vegan diet, gastric surgery, certain medications), serum B12 measurement guides appropriate intervention

Supplements with decades of human clinical trials still show response variability