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The two options included (1) deficit of amino acids produced by fasting, inducing or derepressing enzymes, which transport leucine, and (2) amino acid metabolism depression because of the deficit of glucose (resulting in a deficit of metabolic products of amino acids metabolism which could accelerate uptake) ( 3.2.2.2

Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label extension of the ORION-1 trial

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No sex or race predilection is noted
