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The stress crash theory The stress crash theory suggesting that hypothalamicpituitaryadrenal (HPA) axis hypofunction triggers immune-inflammatory pathways in ME/CFS cannot be substantiated

All references FDA: Concerns with unapproved GLP-1 drugs used for weight loss NEJM (2023): Retatrutide Phase 2 trial in obesity Eli Lilly: Phase 2 retatrutide results published in NEJM Eli Lilly (Dec 2025): Phase 3 TRIUMPH-4 topline results announcement ClinicalTrials.gov: NCT05882045 (TRIUMPH-3) Drugs.com: Retatrutide status & timeline Lilly Trials: TRIUMPH-3 summary page

It is not approved for human or animal use and may not be used in food, drugs, cosmetics, or diagnostic procedures