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In 2018, it was shown that tau overexpression and hyperphosphorylation can induce neuronal loss via ferroptosis, and ALA supplementation effectively inhibited cognitive decline through reducing tau-induced iron overload, lipid peroxidation, and upregulating GPx4 expression in P301S tau transgenic mice

Considering that plants abound in antioxidant compounds, and humans are not predisposed to synthesize the majority of them, new fields of research have emerged

38 A study revealed that tumor-initiating cells become addicted to exogenous methionine because of highly elevated methionine cycle activity

Before launching of the anti-angiogenic therapy from the cradle to its action port, it was described as a therapy of resistant to resistance, owing to the genetic stability of ECs, as anti-angigenic drugs mostly target ECs