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Importantly, recent preclinical studies demonstrate that, like rimonabant, neutral antagonists of CB1 reduce self-administration of 9 -THC and nicotine, and can also prevent cue-induced reinstatement of 9 -THC, nicotine, and cocaine seeking (Gueye et al., 2016

Most people on an aggressive protocol find they want far less of it anyway, since the reward response to food and drink tends to soften across the board

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