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doi: 10.1038/s41392-023-01605-2 59 CorradiGForteDCristianoGPolimenoACiciarelloMSalvestriniVet al

A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila

Moreover, animal and translational studies that suggest plausible neurodevelopmental effects at doses close to the therapeutic range were briefly mentioned in relation to biological plausibility, whereas recent experimental literature points to specific mechanistic hypotheses (e.g., CB1 modulation, OS, sexspecific prefrontal transcriptomic changes, epigenetic programming) deserve more neutral discussion (Philippot et al., 2018[86])

Activated casp-1 forms a heterodimer complex that catalyzes the maturation of IL-1 and IL-18 [321]