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Glutamate toxicity can be reduced by antioxidants, and the psychoactive principle of cannabis, tetrahydrocannabinol (THC), and the non-psychoactive principle cannabidiol (CBD), and other cannabinoids, is found to block glutamate neurotoxicity with a similar potency, and thereby potent antioxidants

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Glucose conjugation facilitates GLUT1-mediated transport across the BBB, resulting in increased neuronal uptake and pronounced neuroprotective effects (103)

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