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This study was supported by the Guangdong Basic and Applied Basic Research Foundation (2024A1515011821), the Science and Technology Projects in Guangzhou (2025A03J4226), and the Longgang District Science and Technology Innovation Bureau Project (LGKCYLWS 2024-9)

Congested (i.e., inferior caval vein and superior mesenteric vein) and failed (azygos vein) blood vessels, multiple organs lesions, heart, lung, liver, kidney, the gastrointestinal tract in particular, and muscle weakness, as well as brain lesions, eye lesions (increased intraocular pressure, retinal ischemia) and oxidative stress in tissues were markedly attenuated [14,15,16,19,20,21,22,23,24,25]

In these patients, when total hepatocyte mass decreases, IGF-I synthesis and glycogen stores decrease (131) resulting in low glucose and intra-portal insulin levels, and a state of hepatic GH resistance ensues