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This study also suggested the protective effect NR supplementation had on alcohol-induced liver injury, whose mechanism could involve the gut microflora-bile acid axis

doi: 10.1016/j.psychres.2018.04.027

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Also, people who have had surgery on their intestines, like weight loss surgery, or have diseases that affect the gut, like Crohns disease or celiac disease, are also at risk of not getting enough vitamin B12
