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PPARgamma-coactivator-1alpha gene transfer reduces neuronal loss and amyloid-beta generation by reducing beta-secretase in an Alzheimers disease model

Nanoaggregates were then stabilised thanks to -lipoic acid polymerization and loaded with doxorubicin: the nanonetwork was selectively cytotoxic against cancer cells with respect to normal cells [195]

However, in PD, -syn monomers undergo misfolding and aggregate into fibrous structures that transfer between neurons and rapidly spread throughout brain regions, causing functional damage and neuronal death (Park et al., 2025)

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