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10.1016/0092-8674(87)90039-0 15 ChaiR.KuoB.WangT.LiawE
For those following a vegetarian or vegan diet, B12 is naturally scarce
This has been observed in clinical practice where 34% of patients co-prescribed metformin alongside PPIs were vitamin B 12 deficient, significantly greater than those on metformin (22%) or PPIs (26%) monotherapy, suggesting an additive effect
Vignoli et al
