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Analytical methods, chromatographic and mass spectrometric conditions Chromatographic and mass spectrometric conditions on the HPLC/MS/MS system were used as described before 34 with some slight modifications

In one study on Watanabe hyperlipidemic rabbits, administration of L-Arg at 1.5% in 1 g/kg body weight/d chow diet for 8 wks resulted in a significant increase in the plasma L-Arg/ADMA ratio, with the authors concluding that the L-Arg/ADMA ratio positively correlates with the progression of atherosclerotic plaques [45]

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ibul et al., 2016) (Fig