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doi: 10.1093/ajhp/53.10.1141
Integrative analysis of 111 reference human epigenomes
In mice, MTHFR deficiency decreases SAM, increases SAH and reduces global DNA methylation, directly associating impaired MTHFR flux to a hypomethylated genome (102,103)
Remarkably, accumulating evidence indicates that miRNAs exert their profound impact on PD pathophysiology by assuming a direct regulatory role in key cellular processes, specifically within mitochondrial and immune pathways 9,10
